No! Once configured (should be quite easy - or happen automatically on modern Linux distributions) it is as easy as it is in Apple's Mac OS or Microsoft's Windows.
It is also nice that you have the same Graphical User Interface regardless which hardware you are acutally using. In Windows for example you get a professional UI with one driver and a car-radio style toy with another. - In Linux you have the same professional User Interface for all scanners.
Other professional features are: a network server and backend for scanning from a remote scanner and a command-line tool, which allows the usage of the scanner from scripts.